This article explores the role of Nature-based Solutions (NbS) in enhancing urban health and well-being, with a focus on the synergy between community-driven innovation. By examining case studies in various urban contexts in Italy (both top-down and bottom-up approaches), we highlight the importance of involving local communities in the development of NbS to address environmental challenges while simultaneously promoting social equity. This article explores the role of Nature-based Solutions (NbS) in enhancing urban health and well-being, with a focus on the synergy between community-driven innovation and urban policy. The findings demonstrate how holistic approaches can lead to sustainable and health-promoting environments that reflect the needs and aspirations of residents.