Overexploitation of the human population since the 1940s has resulted in rapid civilization (industrialization and urbanization) and intensive agricultural practices, leading to an extensive increase in contaminants release. It eventually degrades the natural properties of the environs, i.e., lithosphere as soil, hydrosphere as water, and atmosphere as air. The inorganic soil contaminants because of anthropogenic activities such as industrial dispensing, metals leaking from smelting and mining, automobile exhaustion, chemical fertilizers, pesticides, municipal wastes mainly consist of heavy metals (HMs): arsenic (As), cadmium (Cd), lead (Pb), chromium (Cr), mercury (Hg), copper (Cu), zinc (Zn), and nickel (Ni) which are hazardous to crop/plants and animals then imminently, to human health. Besides, the persistence of HMs in soil pollutes the food chains, negatively impacting the environment. The mitigation of HMs contamination from soil has become of paramount importance since decades ago. It is important to remember that, in the long run, and broad-scale adoption, there are more problems due to high costs and uncooperative ways of implementing the solution of HMs. For a sustainable environment, the introduction of plants into HM-contaminated soil is a mitigation strategy. It depends on the plant species and genotype's potential to uptake and bioaccumulate. It includes phytoextraction, phytostabilization, rhizo-filtration, and phyto-volatilization mechanisms. The plants in contaminated soil induce a biological hotspot with various soil microbial species and enhance the reduction of soil’s HMs concentration. The present chapter attempts to more focus on heavy metals contamination, an overview of phytoremediation, and challenging perspectives. Phytoremediation is the prime approach for a sustainable environment without compromising the health of the plants and human population.