In the context of Industry 4.0, 3D printing is emerging as a transformative technology revolutionizing traditional supply chains with decentralized production and enhanced flexibility. While it is being adopted widely across industries such as medical, automotive, and aerospace and enabling cost reduction and efficient customization, the rapid development of 3D printing raises challenges related to intellectual property (IP) protection, including counterfeiting, plagiarism, and unclear ownership of digital assets like CAD files. Current licensing practices, such as Creative Commons, are insufficient, with many users failing to protect their work, leaving it vulnerable to exploitation. Blockchain technology, combined with non-fungible tokens (NFTs), offers a novel solution to safeguard IP rights in 3D printing. This study explores the integration of blockchain and NFTs into 3D printing ecosystems to enhance ownership authentication, prevent piracy, and establish licensing practices. By converting CAD files into NFTs linked to metadata stored on decentralized platforms like IPFS, creators can secure their designs with transparency and accountability. Additionally, plagiarism detection mechanisms leveraging Constructive Solid Geometry (CSG) and design data ensure originality. The proposed ecosystem shows how blockchain and NFTs can address IP challenges while promoting ethical practices, enabling secure digital asset transactions, and fostering innovation in the growing 3D printing industry. This multidisciplinary approach holds promise for resilient, scalable, and sustainable solutions.