This chapter addresses the ethical, legal, and privacy considerations essential to responsible digital marketing in healthcare. It outlines the risks associated with data collection, targeted advertising, and the use of emerging technologies such as AI and predictive analytics. The chapter emphasizes the importance of safeguarding protected health information (PHI) under HIPAA, obtaining informed patient consent, and ensuring truthful, evidence-based communications. Real-world examples highlight the consequences of privacy breaches and unethical campaigns, while practical strategies guide marketers in balancing engagement with patient confidentiality. Topics include HIPAA compliance requirements, FTC advertising standards, ethical use of social media, cybersecurity best practices, and patient-centered marketing techniques. Appendices provide quick-reference tools, including a PHI guide, consent templates, red-flag checklists, recommended HIPAA-compliant platforms, and an ethical review questionnaire. The chapter concludes with actionable recommendations for integrating accountability, transparency, and respect for patient rights into all healthcare marketing initiatives.