Sulfides in meteorites and in samples returned from asteroids and comets by spacecraft are invaluable to study as sulfides are highly sensitive recorders of the conditions at which they formed and/or were altered. The study of sulfides in astromaterials can be used to constrain fundamental formation conditions and processes of the Solar System, such as the oxygen and sulfur fugacities of formation, the histories of aqueous alteration, thermal metamorphism, space weathering, shock-impact processing, and cooling rate. These constraints are key for understanding the physical and chemical conditions of the formation and alteration of Solar System materials. Here we discuss the array of sulfides present in samples from asteroids and comets, what processes control their presence, how their presence and their compositions inform our understanding of the formation and alteration of material in the early Solar System, recent advances in their understanding, and discuss opportunities for future sulfide analysis endeavors.