This study examines how disruptive technologies such as Artificial Intelligence, Blockchain, and the Internet of Things are transforming supply chain management and accelerating the shift toward Industry 4.0. These technologies are redefining operations by improving transparency, efficiency, and responsiveness while enabling innovative business models. Blockchain offers decentralized and tamper-proof ledgers that enhance trust and traceability across supply networks. Artificial Intelligence supports advanced predictive analytics, demand forecasting, and process automation, reducing costs and strengthening decision-making. The Internet of Things provides real-time visibility through data sharing and monitoring, which enhances logistics and enables agile supply chain operations. Although these technologies present remarkable opportunities, they also pose challenges such as high implementation costs, data integration complexity, scalability concerns, and cybersecurity risks. Even with these barriers, their benefits in terms of cost optimization, operational resilience, and improved customer satisfaction underscore their growing importance. This study emphasizes that organizations should view disruptive technologies not only as tools for efficiency but also as enablers of sustainable growth, competitive advantage, and long-term value creation in global markets.