The adoption of Autonomous Mobile Robots (AMRs) has emerged as a promising solution to enhance efficiency and reduce operational costs for industrial companies. Given the significant cost of AMRs, it is crucial to determine the optimal number and characteristics before making significant investments. This study proposes a decision-support framework based on simulation to assess the impact of integrating AMR robots in a complex distribution center. Additionally, this framework aids decision-makers in determining the optimal fleet size of AMR robots and corresponding charging stations. A simulation model was developed using data from a leading retail company, focusing on pallet movement within the facility, comparing scenarios combining AMRs with other intralogistics implementations. This methodology incorporates uncertainty, variability (statistical distributions to create transportation orders, acceleration, demand and offer fluctuations) and implements fleet management, transportation capacity, demand matching, and resource utilization according to real case scenarios. The proposed model replicates accurate robot coordination and actual deployment environments, ensuring that the tested scenarios approximate the real-world conditions as much as possible. Preliminary findings show results supporting the decision-making for a fleet size to meet weekly production targets, optimize robot utilization, and coordinate charging instances to prevent production stops. Conclusions suggest that the proposed simulation approach is an effective tool for planning and implementing logistics solutions, enabling users to make informed decisions before investing.