Energy-increasing costs, recurrent power outages, and reliance on coal-fired electricity emphasize the critical need for energy efficiency, particularly in South African healthcare facilities. The paper aims to optimize a South African hospital’s medical heating equipment energy efficiency by establishing baseline data to increase energy economy while maintaining operational reliability and patient care quality. The study used a case study approach and quantitative data analysis to assess HVAC systems and medical heating equipment by integrating current energy-efficient technologies and operational measures such as targeted maintenance and energy audits, resulting in a 20% reduction in energy use. The study underlined the need to establish energy consumption baselines to track progress and maintain long-term sustainability. The study contributes to sustainability in healthcare by giving actionable insights into medical heating equipment m minimization of the total power consumption of an HVAC system by optimizing the inlet chilled water temperature and water mass flow rate to reduce chiller power consumption and pump fan power consumption and a replicable methodology for improving energy efficiency in a variety of contexts, including South Africa and beyond.