Monkeypox has re-emerged as a serious public health threat with global implications. This chapter focuses on sustainable containment mechanisms by exploring the intersection of public health infrastructure, environmental stewardship, and infectious disease preparedness. It emphasizes the ecological and anthropogenic factors contributing to outbreaks, such as habitat encroachment, wildlife trade, climate change, and urban expansion, which collectively increase zoonotic spillover risks. Environmentally grounded strategies like habitat preservation, biodiversity conservation, and sustainable land-use planning are presented as foundational to long-term monkeypox prevention. The chapter also explores the role of effective vaccination programs, enhanced surveillance systems, laboratory capacity building, and rapid outbreak response protocols. Particular attention is given to integrating One Health principles, which recognize the interdependence of human, animal, and environmental health. Cultural competence, community engagement, and misinformation countermeasures are also addressed to ensure equitable and stigma-free disease control. Drawing lessons from previous epidemics, including Ebola and COVID-19, the chapter advocates for a coordinated, multidisciplinary strategy to strengthen global preparedness. Governance and policy frameworks are discussed as critical drivers of sustained monkeypox management, particularly those supporting intersectoral collaboration, legal enforcement of containment measures, and alignment with international health regulations. The chapter concludes with a call to action for global and local stakeholders to invest in long-term resilience through environmentally sound and socially inclusive approaches. By doing so, the global community can better mitigate the impact of monkeypox and other zoonotic threats in a changing world.