The disease caused by the injection of permanent synthetic fillers in the gluteal region is a public health issue, particularly in Latin America. It is characterized by chronic pain, persistent inflammation, granuloma formation, fibrosis, and myositis, with or without infection. A significant complication is the migration of the material to other areas, such as the lumbosacral region or lower limbs, which can cause severe damage and significantly compromise the patient’s quality of life. Currently, experts in the field have reached a medical consensus on the standard approach to treatment. An open surgical technique involving a “butterfly-wing” incision has been described. This approach enables precise removal of affected tissues and eliminates a high percentage of the injected substances. This integrated approach is proposed as the safest and most effective treatment. It combines proper diagnosis, advanced surgery, and postoperative follow-up to significantly improve the affected patients’ outcomes.