Introduction: Unilateral axillary adenopathy in an adult female patient should always generate the suspicion of a neoplastic disease, which should be studied. Lymphadenopathy due to silicones is a sporadic side effect of breast enlargement with implants or silicone injection. It is a benign pathology. The most frequently affected lymph nodes are axillary lymph nodes. The magnitude of the problem will depend on the degree of lymph node infiltration, the number of affected lymph nodes, and the reaction of the surrounding tissues. Treatment: Discarding a mammary neoplastic pathology is the first gesture. Once malignancy has been ruled out, the source of silicones must be evaluated and resolved. Expectant management can be adopted with the silicone-affected lymph nodes or, if necessary, symptomatic treatment with immunomodulators. If, despite medical treatment, painful masses persist, the siliconomas can be removed conservatively. Neurosurgeons and vascular surgeons should be called if the brachial or vascular plexus is involved. Conclusion: The most important differential diagnosis is the neoplastic origin of the adenopathy. Silicone lymphadenopathy is a rare complication of procedures involving silicones. The source of silicones must be evaluated and resolved. Symptomatic patients must first be treated with medical treatment.