This chapter examines the challenges of breast cancer prevention in women with silicone-injected breasts. While global efforts and technological advances have reduced mortality through early detection, silicone injections—often performed illegally—create significant diagnostic barriers. Injected silicone causes dense opacities on imaging, mimicking or obscuring tumors, delaying diagnosis. Despite no confirmed link between silicone and cancer, the compromised imaging severely limits preventive strategies like mammography and magnetic resonance imaging (MRI). Surgical intervention is often the only viable option for affected women. The chapter also discusses newer injectable materials like hyaluronic acid (e.g., Macrolane™), which pose similar diagnostic concerns and have been banned in several countries. Emphasis is placed on assessing individual risk using models like Gail and CLAUS, and on multidisciplinary approaches for treatment and prevention. Ultimately, the pursuit of aesthetic enhancement through unsafe methods undermines decades of progress in breast cancer detection.