The cultural pursuit of idealized body aesthetics has long influenced beauty practices in Latin America, culminating in the widespread use of illegal injectable materials for cosmetic enhancement. This chapter delves into the historical evolution, medical ramifications, and legislative responses to these practices, with a particular focus on Colombia, where the phenomenon has reached critical proportions. The analysis builds on pivotal work by Professor Coiffman, who introduced the term “Iatrogenic Allogenosis” to describe complications stemming from these materials. Subsequent studies have identified the condition now known as biopolymer-induced human adjuvant disease (BHAD) and PERFILD (PERmanent FILler Disease). Affecting millions across the region, the use of these materials for cosmetic enhancement has resulted in a broad spectrum of complications, ranging from localized tissue damage to systemic inflammation and autoimmune-like syndromes. Predominantly impacting women from lower socioeconomic backgrounds, this condition underscores the intersection of public health and social inequities.