Scholarlink

In the context of drug discovery, many promising biological targets have been studied. In particular, enzymes have been identified as playing a central role in a wide range of diseases. Enzyme inhibition has been used for therapeutic intervention aimed at mitigating disease effects in humans, animals and plants. Upon selecting an enzyme of interest, the researcher explores its mechanism and metabolic role, analyzes its protein sequence and structure, and reviews the literature for evidence of its involvement in pathogenicity. Herein, phosphoglucomutase (PGM) was chosen for a mechanism overview, multiple sequence alignment, phylogenetic tree analysis, and structural search in Protein Data Bank (PDB). Lastly, we investigate reports of PGM expression in a diversity of pathogens.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

α-d-Phosphoglucomutase: A Promising Target in Carbohydrate Formation

  • 章节

  • 发表日期：

    2025年

查看全文
  • Gabriel Alves De Jong,
  • Carlos Henrique Tomich de Paula da Silva

摘要

In the context of drug discovery, many promising biological targets have been studied. In particular, enzymes have been identified as playing a central role in a wide range of diseases. Enzyme inhibition has been used for therapeutic intervention aimed at mitigating disease effects in humans, animals and plants. Upon selecting an enzyme of interest, the researcher explores its mechanism and metabolic role, analyzes its protein sequence and structure, and reviews the literature for evidence of its involvement in pathogenicity. Herein, phosphoglucomutase (PGM) was chosen for a mechanism overview, multiple sequence alignment, phylogenetic tree analysis, and structural search in Protein Data Bank (PDB). Lastly, we investigate reports of PGM expression in a diversity of pathogens.