The restoration of endodontically treated teeth must be considered as an integral part of the endodontic treatment, since it plays a major role in the long-term success of the procedure, as well as in tooth longevity. To maximize the chances of success, the specificities of endodontically treated molars need to be carefully considered, as well as the recent advances in adhesion, digital technologies, and biomaterials. This chapter will critically discuss important aspects such as reinforcement, restoration retention, the need for a ferrule and/or for posts, and the importance of cuspal coverage. Best-practice recommendations will be made, with a particular focus on tissue preservation.