Despite the high enrollment of females in higher education, married Muslim women in Malaysia encounter persistent barriers to their participation in the labor force due to socio-cultural, religious, and institutional constraints. This is a conceptual paper regarding the challenges faced by married Muslim women on employability in the Malaysian business sector. Although the education level has improved markedly among this group, their participation rate in the labour force is still disproportionately low. The study synthesizes findings from previous studies and proposes a conceptual framework in which spousal support and workplace flexibility are the two primary antecedents, while work-life balance acts as a mediating variable that affects the different facets of employability among women (employment status, job readiness, job retention, and job satisfaction). The model aims to inform empirical studies and policy, and organizational practices rooted in socio-cultural and institutional contexts in the future. This paper provides insights into a culturally embedded framework that highlights the importance of considering holistic and context-sensitive solutions to increase female labour participation in Malaysia.