This chapter explores the complexities of interventions and case management in the context of disengagement from radicalization to violence. It begins by addressing the definitional challenges surrounding key concepts such as deradicalization and disengagement, highlighting the lack of consensus and the implications for direct intervention practice. Emerging evidence in secondary and tertiary psychosocial CVE programming are subsequently discussed. It then introduces case management as a structured, client-centered approach that aims to steer individuals away from extremist attitudes and behaviors through tailored interventions that often require coordination across multiple systems. By drawing on social work’s bio-psycho-social-spiritual model, effective direct practice and case management emphasize the importance of holistic engagement and assessment. Assessment and intervention tools are critical to understanding and addressing the multiple vulnerabilities, needs, and strengths of individuals in order to develop interventions that not only reduce risk, but also empower individuals in their environments aiming to promote sustainable disengagement from extremism. This chapter highlights the need for specialized competencies for social workers and other psychosocial professionals, including in trauma-informed care, and the importance of evaluation and adaptation of interventions to meet the evolving needs of clients, emphasizing a strengths-based approach to supporting client’s social reintegration.