The research and exploitation of the industrial production and applications of bacterial cellulose (BC) have been predominantly driven by Komagataeibacter, Acetobacter, and Gluconacetobacter species, as these genera are generally regarded as high cellulose producers. However, non-conventional genera, such as Enterobacter, Rhodococcus, Bacillus, and Leifsonia, have shown promising potential to overcome key production limitations, including oxygen dependence, low yield under stress, and limited substrate utilization. A deeper understanding of the biology, metabolism, and cultivation conditions of these alternative producers can thus prove to be crucial for the development of new BC production methods. Expanding research on these genera could lead to significant advances in the efficiency, scalability, and sustainability of BC production, ultimately accelerating its industrial and commercial applications.