In this chapter, we argue that the African universe is a panpsychist universe in which God is the highest consciousness. We explore African religious and philosophical thought on the nature of God and argue that African vitalism achieves its fullest meaning in panpsychism. While vitalism is the view that everything in the universe is animated by a life principle in varying degrees, panpsychism is the claim that consciousness or mind-stuff is fundamental in the universe. We identify the conflict between traditional African theism and the limited God views in the literature and opt for the former framework for the purpose of this chapter. Working within the framework of traditional African theism, we argue that God is the supreme consciousness of the universe whose being accounts for the instances of mind-stuff and matter in the world. We note the problem of interaction that arises when one commits to the idea that consciousness is fundamental in the physical universe. We tentatively suggest that the answer to the question of how mind and matter interact with each other may lie in regarding matter as an aspect of mind and leave the final resolution of the problem of interaction for future research.