The article presents the assessment of operating costs and energy performance of family houses. Experimental and statistical modeling was carried out to optimize the energy and economic coefficients of single family houses. The analysis of energy, ecological and economic factors allows for the selection of rational options for external enclosures and ventilation systems. A graphical analysis of the influence of variable factors on the value of operating costs of houses using gravitational and mechanical ventilation is presented. The results of calculating the operating costs of a single-family house depending on the heat transfer coefficient U and the value of the primary energy EP using the regression equation show that for buildings with mechanical ventilation, the minimum operating costs obtained were Ymin = 229.1 EURO/year for a low-energy house (U = 0.10 W/(m2K)) with EP = 41.25 kWh/(m2y). Reducing energy consumption in buildings, which is closely related to the use of thermal insulation of external, leads to energy-efficient construction with low operation costs (nearly zero-energy, passive and plus-energy buildings). The development of a system for managing energy efficiency parameters at all stages of the house’s life cycle defines the concept of integrated design of low-energy houses and can be the basis for optimizing sustainability in the construction sector.