In the paper, the theoretical grounds and methodologies of spatial resilience’s estimation are represented. A European tool to measure resilience across such key dimensions as social, economic, green, digital, and geopolitical is described. Environmental resilience is defined as the ability of an ecosystem to maintain its structure and functions, adapt to altering conditions, resist disturbances, recover from aftershocks, and transform if necessary. The procedure to estimate the resilience of Ukraine’s regions based on indices of environmental safety is presented with the steps of variables’ selection, standardization, weighting, and aggregation. The resilience’s scores for regions of Ukraine have been calculated for the years 2015 and 2020, and the regions have been differentiated into five groups depending on the resilience’s score. Variables like land, forest, water resources, and waste management have been considered for the differentiation.