Personalized environmental comfort systems (PECS) are an emerging solution able to combine increased environmental comfort conditions for users and, if correctly designed and operated, to improve the building energy performance. This paper explores the potentialities of PECS for lighting and cooling to reduce energy uses in comparison with conventional technologies in a Living Lab, implemented in an office building in the Casaccia Research Center of ENEA. It consists of 11 rooms, 7 west oriented and 4 facing east, hosting one or two workers. Each room has a direct expansion reversible air conditioning unit, and it is equipped with six neon lamps placed in three luminaries. In seven rooms, each worker has a desk cooling fan and a desk lamp. In the four control rooms the workers were able to switch on the air conditioning unit and the electric lighting according to their preferences; in the rooms equipped with the PECS, the users were free to use the desk devices, with cooling unit set to 28 °C. The study reports the results of a preliminary test carried out for two weeks in July 2024. Questionnaire results show that the thermal sensation is similar for users with and without PECS (neutral for about 70% of the sample), while the PECS users experienced a better air quality (only 5% evaluated the air slightly used). Few energy tests demonstrated that PECS may provide relevant cooling energy savings.