Creating acceptable indoor air quality (IAQ) is vital for managing built environments. IAQ is achieved by ventilating spaces to keep pollutants like CO2, humidity, particulate matter, and VOCs within healthy concentrations. The effectiveness of ventilation strategies depends on factors such as occupancy, pollutant types, and air terminal devices, which are influenced by outdoor air quality, particularly in urban areas. Demand-controlled ventilation (DCV) based on indoor CO2 levels has shown better energy efficiency than constant-flow systems. However, for over 40 years, France has adopted humidity-based demand-controlled air terminal devices (HDC-ATDs), particularly in residential buildings. While these devices regulate airflow based on humidity, their impact on overall IAQ is rarely studied. This study aims to design a climatic chamber to evaluate ventilation strategies using HDC-ATDs. The chamber consists of three zones: a buffer simulating polluted outdoor air, and two connected interior zones resembling a residential space. Pollutants are introduced and maintained at constant levels in the buffer zone, while airflow is mechanically controlled. The setup allows for testing different airtightness levels and pollutant transfer between zones. The chamber’s design is guided by numerical simulations. On one hand, CONTAM model was used to determine the emission rates of pollutants and the corresponding sizing of the generators and the proper selection of the control equipment (sensors, mass flow controllers). On the other, the CFD model assisted in determining the appropriate location of these various instruments for better control as well as proper functioning of the experimental chamber.