The growing demand for energy and poor indoor air quality (IAQ) in buildings call for sustainable HVAC solutions, as cooling systems account for nearly 70% of total energy use. This study introduces a novel system that combines a radiative cooling panel integrated into a wall with an impinging jet ventilation (IJV) system to enhance thermal comfort and IAQ. The system is tested in a 3 m × 3 m × 2.9 m room simulating an office occupied by two people. A 3 m × 2.335 m × 0.18 m plenum inside one wall contains a network of copper water tubes, where water enters at 14 ℃ with a flow rate of 2 m3/h. The radiative panel absorbs heat from the room, while ventilation air is pre-cooled before being released at 56.5 cm above the floor, creating a thin layer that spreads due to buoyancy forces. Experimental results demonstrate that the radiative cooling panel serves as the primary cooling mechanism, maintaining a head-to-ankle temperature difference of less than 1 ℃, within ASHRAE comfort limits. The IJV system effectively enhances ventilation performance, achieving a comparable IAQ level at lower airflow rates, leading to potential energy savings. Additionally, reducing the airflow rate from 0.039 m3/s to 0.025 m3/s had a minimal impact on thermal conditions, reinforcing the efficiency of the combined system. These findings highlight the potential of integrating radiative cooling with impinging jet ventilation as a sustainable approach for cooling buildings in extreme climates.