Automated road transport mobility will develop only if fundamental conditions are fulfilled: acceptance by users and citizens, economic sustainability, contribution to a more sustainable mobility and last but not least, demonstration of its safety. Fulfillment of these conditions needs to be addressed by policymakers through regulations, standards, guidance, assessments and stakeholders’ involvement. France built its regulatory framework on this balance by assuming safety will be the main factor for other conditions for the development of automated road transport systems to be reached. This paper presents the safety demonstration framework, methods and tools for the development of automated road mobility. The main guiding principle underlying this safety-first based framework lies in the scenario-based approach aiming at the best possible coverage of driving situations that such systems should be required to encounter and address safely. This paper will present two aspects of this approach, articulated with conventional safety demonstration activities: scenario generation approach based on layers and its articulation with ODD description and OED definition.