Oxidoreductases, which consist of laccases, horseradish peroxidases (HRPs), manganese-based totally peroxidases (MnPs), tyrosinases, and lignin peroxidases (LiPs), are notably implemented in the approach of bioremediation for different hazardous compounds. These compounds consist of pharmaceuticals, dyes, bisphenols, phenols, and their derivatives and so on. Due to their low substrate requirements and their capability to catalyze oxidation reactions for chemical compounds, laccase and horseradish peroxidase are commonly used to degrade pollutants. Thus, this review will discuss the diverse techniques of immobilization along with application of the laccase and horseradish peroxidase to remove different pollutants. It is also will explore the micropollutants types along with its detection methods. Furthermore, the limitations faced by laccase and horseradish peroxidase as oxidoreductases will be examined, along with the potential for their future development.