The presence of fluoride up to a certain level in water could benefit human health due to its importance for bones and teeth; however, elevated fluoride concentrations could cause many diseases, such as skeletal fluorosis and infertility in women. Therefore, many treatment methods were suggested and applied to decrease the fluoride concentrations in water to the permitted limitations (1.5 mg/L as stated by the WHO). One of the most efficient methods that has recently been investigated as an alternative to traditional methods is electrocoagulation (EC). Thus, the latter is applied to eliminate fluoride from synthetic water samples in the present work. The used EC is made from a rectangular Perspex basin (20, 10 and 5 cm in length, width and depth, respectively) supplied with two iron square electrodes ( \(5cm\times 5cm\) ). The performance of this EC unit, in terms of fluoride removals, was optimised for the effects of the detention time (DT) (0 to 60 min), initial pH (ipH) (4, 7 and 10), applied voltage (AV) (5, 10 and 15 V), and spaces between electrodes (SBE) (5, 10 and 15 mm). The findings of this study prove that the iron electrodes decreased the residual fluoride from 5 mg/L to 1.5 mg/L after 50 min of DT at ipH of 10, AV of 15 V and SBE of 5 mm. In conclusion, the findings of this investigation proved that the iron-based EC cells meet the limitations of fluoride in drinking water within a reasonable period.