This chapter covers current status and future directions of school-based resilience programs on how they empower students to overcome mental health challenges and thrive. Research shows adolescents’ mental health is critical, with rates of youth distress and depression on the rise around the world. Reports spread to the school environment where students experience anxiety, stress, fatigue, and see their quality of life altered. On the other hand, schools may also act as ideal settings for implementing resilience programs to help address these alarming observations. Resilience, understood as a dynamic process influenced by internal and external factors, is a pivotal component of these programs. Two types of school-based resilience interventions are identified: standalone programs and whole-school approaches. Standalone programs (e.g., Penn Resiliency Program: depression prevention) focus on explicit teaching of resilience-related skills. In contrast, whole-school approaches aim to create positive school environments integrating resilience and well-being education across all aspects and all levels of the school. A recent review revealed that while both types of programs show promise in reducing distress and enhancing well-being, standalone programs prioritize distress reduction. Typically, key recommendations for effective resilience programs include the need for interventions to address both ill-being and well-being, along with the need to integrate such educational initiatives into the ethos and functioning of the entire school. Additionally, a recent study explored the balance between perceived demands and resources, as well as the role of optimism, in influencing resilience and school burnout. Ultimately, while schools and governments around the world have not yet fully incorporated well-being and resilience into policies and into initial teacher education, findings from these studies underscore the need to integrate resilience education in a systemic way, targeting both the reduction of ill-being and the promotion of well-being and resources (personal strengths and external resources present in the environment).