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Magnesium is an essential mineral that functions as a cofactor in over 300 enzymatic reactions, but remains a frequent deficiency state due to inadequate dietary intake and faulty absorption. The pharmacological rationale for multi-form magnesium supplementation to enhance systemic bioavailability, reduce gastrointestinal side effects, and sustain tissue-specific physiological processes is the subject of this review. Magnesium Breakthrough™, a seven-magnesium complex supplement, is a model of evidence-based formulation. This paper highlights using solubility assays, model GI digestion, and Caco-2 cell transport models in the supplement industry to measure absorption properties. It also suggests a novel approach in building a synergistic formula composed of different forms of the same element due to their unique characteristics. Based on a thorough literature review, it is seen that organic structures such as bisglycinate, malate, and Sucrosomial® magnesium demonstrate better tolerability and solubility, while threonate, taurate, and orotate may provide benefits for neurological function, cardiovascular function, and mitochondrial health. Together, the outcomes support a multi-form strategy as a coordinated strategy for optimizing magnesium delivery, enhancing physiological action, and achieving long-term compliance.

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Multi-Form Magnesium Supplementation: A Review of Bioavailability, Bioaccessibility, and Purity Considerations with Magnesium Breakthrough™ as a Case Example

  • 会议论文

  • 发表日期：

    2026年

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  • Matt Gallant,
  • Neira Crnčević,
  • Katarina Hafner-Vuk,
  • Dženan Kovačić,
  • Muamer Dizdar,
  • Monia Avdić

摘要

Magnesium is an essential mineral that functions as a cofactor in over 300 enzymatic reactions, but remains a frequent deficiency state due to inadequate dietary intake and faulty absorption. The pharmacological rationale for multi-form magnesium supplementation to enhance systemic bioavailability, reduce gastrointestinal side effects, and sustain tissue-specific physiological processes is the subject of this review. Magnesium Breakthrough™, a seven-magnesium complex supplement, is a model of evidence-based formulation. This paper highlights using solubility assays, model GI digestion, and Caco-2 cell transport models in the supplement industry to measure absorption properties. It also suggests a novel approach in building a synergistic formula composed of different forms of the same element due to their unique characteristics. Based on a thorough literature review, it is seen that organic structures such as bisglycinate, malate, and Sucrosomial® magnesium demonstrate better tolerability and solubility, while threonate, taurate, and orotate may provide benefits for neurological function, cardiovascular function, and mitochondrial health. Together, the outcomes support a multi-form strategy as a coordinated strategy for optimizing magnesium delivery, enhancing physiological action, and achieving long-term compliance.