Mid- and post-pandemic attendance to hemodialysis centers decreased due to the population’s inability to cope with the cost of treatment. Patients reduced the number of sessions per week, decreasing health quality. Our work involves using several techniques to improve the efficacy of hemodialytic treatments. Previous work involved exercising during the HD sessions, monitoring body composition, and heart rate variability analysis, which showed increased cardiovascular fitness and reduced adverse effects. In this work, we analyzed whether using new advanced filer membranes during HD sessions, applied twice weekly instead of the conventional 3x per week, could lead to equal or better outcomes. We compared three HD filtering techniques: standard therapy vs. High flux HD and extended HD (theranova filter). Several metabolites were studied pre and post-session: β2-microglobulin, urea, and phosphorous. The results show that the β2-microglobulin clearance was 20% better than the standard treatment, while urea clearance was 5% better using HDx and 8% better using HDfx, and Phosphorous clearance was 3% better using HDx while HDfx was 2% better. The most important figure is the β2-microglobulin clearance since this is an essential marker in the quality of therapy and is not usually removed in conventional HD. We believe that using both advancements (exercise, HRV, body composition, and nutrition) and adopting advanced filtering techniques will significantly increase the effectiveness of treatment and quality of life.