Traumatic spinal cord injuries (TSCI) occur primarily in motor vehicle accidents, violent events, falls, and sports accidents. Depending on their severity, they can produce paralysis, numbness, and permanent dysfunction from the injury site to the lower body. The longer the injury, the lower the likelihood of recovery. Therapeutic strategies applied to date to preserve and restore neurological function have been unsuccessful; therefore, multidisciplinary therapeutic strategies may need to be integrated to allow the development of functional treatments. Experimental strategies to restore neurological function after TSCI include the use of biopolymers to promote plasticity, axonal growth, and neuronal connectivity. Amine-rich polymeric materials are known to improve surface biocompatibility and have a favorable relationship with central nervous system tissue. In this work, we studied the effect of iodine-doped polypyrrole (PPy/I) on chronic moderate-contusion TSCI in rats. Treatment with PPy/I is shown to have a favorable effect on functional recovery, even when the treatment was administered during the chronic phase. This evidence demonstrates therapeutic potential with clinical efficacy.