Gas embolism is a rare but potentially life-threatening condition characterized by the presence of gas bubbles within the vascular system. It can result from various causes, such as diving accidents, medical procedures, or trauma. The severity of symptoms can range from mild neurological deficits to severe multiorgan dysfunction, emphasizing the need for prompt and effective treatment. hyperbaric oxygen therapy (HBOT) has emerged as a crucial intervention in the management of gas embolism, offering a unique approach to improve patient outcomes. This chapter explores the pathophysiology of gas embolism, the mechanisms of action of hyperbaric oxygen, and the current evidence supporting its efficacy in treating this challenging condition. This chapter also discusses the practical aspects of implementing HBOT in the management of gas embolism and potential complications. Timely initiation of HBOT is crucial, and the decision to use this therapy should be based on a combination of clinical presentation, diagnostic imaging, and the specific circumstances surrounding the gas embolism event. While HBOT is generally considered safe, complications such as barotrauma, oxygen toxicity, and claustrophobia may occur, necessitating careful consideration and supervision during treatment.