This chapter will call modern attitudes and morality surrounding health and wellbeing ‘wellness’, argue that substance use is central to wellness, then that the so-called addictions are residual problematic consequences of the accepted and encouraged use of substances and to the widespread general message that substances, such as pharmaceuticals, vitamins and ‘health’ foods, can and should enhance wellness. Addiction is actually defined and occurs at the human level where laws, policies, social norms, beliefs and attitudes interact with personal disposition, including neuropsychopharmacology. It has been challenging to redress addiction with neuropsychopharmacological interventions alone. Moreover, different substances move in and out of ‘addiction’ and ‘wellness’. The unrestrained pursuit of wellness can turn into addiction; dependence upon a substance or a behaviour for continued wellbeing, despite adverse effects. It is therefore argued that advocating for wellness inadvertently promotes addiction.