Bronchiectasis and chronic obstructive pulmonary disease (COPD) share many of the same symptoms and signs, such as airway inflammation and collapse, airflow restriction, and multiple doctor’s appointments and hospital stays. Radiographical findings of bronchial dilatation on computed tomographic (CT) scans and clinical evidence of persistent coughing up of mucus most days of the year are both necessary for a diagnosis of chronic obstructive pulmonary disease (COPD). Chronic airway inflammation causes pathologic airway dilation and wall thickening, which in turn causes bronchiectasis. In terms of clinical presentation, this is characterized by a persistent cough, thick, daily sputum production, and an increased risk of upper airway infections, also known as bronchiectasis exacerbations. Deterioration of lung function, worsening of quality of life, and chronic neutrophilic airway inflammation are all consequences of acute exacerbations.