In addition to functional recovery, the key result of a TMJ regeneration strategy should be the absence of the main problems of designed TMJ replacements—ossified or fibrous adhesions—over the long term. Engineered TMJ scaffolds containing pro-regenerative active molecules should likewise be able to ward against adhesions and ossifications. Comparing the TMJ cartilage to other hyaline articular cartilages reveals significant histological differences. Because of its unusual composition and intricate structure, articular cartilage regeneration presents a considerable challenge. When the temporal ganglia (TMJ) regenerates, a mandibular condyle implant containing the patient’s cartilage and bone can be created using a single osteochondral construct. Optimal scaffolds comprising active compounds that can independently regulate chondrogenesis and osteogenesis pose a challenge to TMJ regeneration by encouraging matrix formation and the tissue maturation of chondrogenic and osteogenic cells.