Mesotherapy, also known as local intradermal therapy (LIT), is a Greek word that refers to a medical or cosmetic procedure involving tiny needles to provide a precise amount of medication to the mesoderm layer of the skin. Injection sites for mesotherapy include the epidermis, dermis, subcutaneous, and regional areas. Mesotherapy primarily employs hormonal agents, nutrients, potent vitamins, enzymes, vasodilators, muscle relaxants, antiinflammatory, mineral, vaccination, antibiotic, proteolytic enzyme, anesthetic, and antioxidant properties. The main medical indications of mesotherapy include improving blood flow, removing fibrotic tissue, increasing the quality and amount of connective tissue, reversing hair loss (mesohair), rejuvenating the skin (mesoglow), reducing cellulite and excess fat, improving lymphatic drainage, alleviating pain from osteoarthritis, and more. Most commonly associated with the ear, nose, and throat (ENT) sector includes migraines, neck discomfort, oral, and cosmetic mesotherapy.