Negative symptoms are common and pervasive in people living with schizophrenia. These symptoms significantly impact an individual’s life and are strong predictors of functional outcomes. However, they are often underrecognized and undertreated compared to positive symptoms. Addressing negative symptoms requires a multimodal approach. Cognitive impairment represents a core feature of schizophrenia, is present at any stage of the disease and in subjects at high risk for psychosis, and also has a significant impact on patients’ psychosocial functioning. Also in this case, treatment of cognitive symptoms requires a multimodal approach. However, the relationships between cognitive and negative dimensions of schizophrenia are still poorly addressed and understood. Both negative and cognitive symptoms may be in part secondary to the other dimension, and treating each of them could be beneficial also on the other. A core part of these dimensions remains however independent and may represent a nuclear feature of the disease process in the lifespan of patients living with schizophrenia.