This chapter examines the multifaceted challenges faced by nurses when bearing witness to trauma and violence, and proposes multilevel responses to mitigate associated harms. It utilizes a social ecological model to analyze how vicarious trauma, moral distress, workplace violence, and structural inequities impact nurses at individual, organizational, and systemic levels. The chapter argues that addressing these issues requires a holistic approach integrating personal and institutional interventions. At the individual level, it explores trauma stewardship, self-care practices, and coping strategies to build resilience. Organizational responses focus on creating healthy work environments through improved communication, collaboration, leadership, and staffing. System-level approaches examine policies, legislation, and international guidelines aimed at protecting healthcare workers and promoting equitable practices. The chapter emphasizes that while individual coping strategies are valuable, they must be complemented by organizational support and systemic change. It advocates for adequate resources, training, and support mechanisms to empower nurses in navigating complex roles. By synthesizing research, practice, and advocacy, the chapter aims to foster a culture of care that safeguards both patients and healthcare professionals. Ultimately, it calls for transforming healthcare environments to enable nurses to practice with resilience, compassion, and unwavering commitment to well-being.