Using a decolonial lens, this chapter provides an overview of the disproportionate burden of family violence among Indigenous communities, from both a theoretical and epidemiological perspective. The impact of colonization on Indigenous (a term used to refer globally to First Nations, Aboriginal, Inuit, Native American, Métis, Tangata Whenua, and other groups) peoples will be addressed, including a discussion on how colonization is directly related to the high rates of family violence experienced in Indigenous communities. Theories of Indigenous peoples’ coping and resilience are woven throughout the chapter to encourage a strengths-based discourse regarding interventions for Indigenous women exposed to family violence throughout the life course. Examples of Indigenous-led violence prevention interventions from the United States, Canada, Australia, and Aotearoa (New Zealand) are discussed. Cultural safety, a hallmark of Indigenous violence research and care, is introduced as a framework through which non-Indigenous nurses can work with Indigenous clients in an affirming way.