Blockchain technology typically relies on classical cryptographic hash functions, such as SHA-256 and SHA-3, to ensure data integrity and enable trustless verification. However, emerging quantum algorithms will gradually undermine the collision and preimage resistance of these conventional hashes. This underscores the urgent need to efficiently and securely compare and validate large volumes of data. In this paper, we propose the integration of Quantum Fingerprinting as a validation mechanism for string comparisons. Additionally, we extend Quantum Fingerprinting to serve as integrity validation protocol designed for blockchain security. This approach leverages quantum superposition and interference to encode classical transaction data efficiently into quantum states. Experimental outcomes demonstrate that Quantum Fingerprinting not only maintains high fidelity when processing identical inputs, but also effectively distinguishes non-identical data and reliably validates data integrity. This work demonstrates that quantum fingerprinting-based protocols provide initial, practical steps toward a quantum-safe blockchain by addressing current challenges and anticipating future quantum attacks.