The article discusses issues and case studies of using advanced digital technologies in space activities. The relevance of the research is due to the need to increase the efficiency of enterprises in the Russian Federation. This work provides an overview of modern digital technologies and case studies of their application in high-tech production worldwide and in Russia. An analysis of the applied digital technologies and the economic effects of their use in space activities was carried out. The results of the review showed that the implementation of digital technologies in high-tech enterprises can not only improve quality but also reduce the time required to complete certain tasks, costs, and more. Recommendations for a digitalization strategy in space activities are proposed.