Cultural heritage assets are constantly subject to interactions with their environment, undergoing changes often referred to as weathering processes. Climate change constitutes an additional threat, as it intensifies the expected decay processes and contributes to the manifestation of new forms of deterioration. This research project is based on the experiment of an innovative method that can support and increase scientific knowledge on the impact of climate change on cultural heritage. The project aims to use reaction path modelling to study the processes involved in the degradation of cultural heritage. This aim will be supported by a traditional diagnostic analysis, conducted simultaneously, to identify alteration and decay phenomena. The expected output will provide data on degradation processes, expressed in terms of mineral dissolution and secondary product formation.