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Recent work implicates abnormalities of metabolic pathways and processes in severe mental illness (SMI). SMI encompasses moderate to severe mood disorders, as well as schizophrenia spectrum psychotic disorders. Metabolic systems implicated in SMI include mitochondrial function, glucose utilization, and insulin signaling, among others, with evidence suggesting changes in these systems are influenced by genetic, epigenetic, and environmental factors. This chapter reviews seminal studies that explore these metabolic perturbations and disruptions in SMI, with a focus on schizophrenia, bipolar disorder, and major depressive disorder. Specific suggestions for future directions are proposed to advance our understanding of these often life-changing disorders.

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What Is the Best Evidence for Bioenergetic Abnormalities in Severe Mental Illness?

  • 章节

  • 出版模式：

    开放获取

  • 发表日期：

    2025年

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  • Hunter Eby,
  • Ali Sajid Imami,
  • William G. Ryan V,
  • Smita Sahay,
  • John Vergis,
  • Jennifer H. Nguyen,
  • Taylen O. Arvay,
  • Priyanka Pulvender,
  • Nicholas Henkel,
  • Robert E. McCullumsmith

摘要

Recent work implicates abnormalities of metabolic pathways and processes in severe mental illness (SMI). SMI encompasses moderate to severe mood disorders, as well as schizophrenia spectrum psychotic disorders. Metabolic systems implicated in SMI include mitochondrial function, glucose utilization, and insulin signaling, among others, with evidence suggesting changes in these systems are influenced by genetic, epigenetic, and environmental factors. This chapter reviews seminal studies that explore these metabolic perturbations and disruptions in SMI, with a focus on schizophrenia, bipolar disorder, and major depressive disorder. Specific suggestions for future directions are proposed to advance our understanding of these often life-changing disorders.