Machining is the method of material removal by mechanical wear, widely implemented in the industry for fabrication of parts. In the context of drilling, chromium-based coating is important to improve the lifespan of drills and to reduce the manufacturing costs. On the other hand, there is limited knowledge about the real effectiveness of this type of tool on different materials. Thus, this study aims to evaluate the lifespan of this cutting tool on three different substrates: 7075-T6 aluminum alloy, AISI 1045 steel and stainless steel AISI 304. To accomplish that, the Taguchi methodology was employed for the Design of Experiments (DOE), and an Alicona Infinity Focus SL microscope has been utilized to observe the wear on the drills. In this way, the cutting tools were applied to different drilling conditions for evaluation. Therefore, the study concluded that the drill performs better on aluminum 7075-T6 and AISI 1045 steel, but cannot be applied to stainless steel.