Formal mentoring programs have been associated with positive outcomes for youth across childhood, adolescence, and emerging adulthood, demonstrating a potential to impact many important areas of development. However, with so many potential outcomes to focus on, it can be challenging for mentors to identify and prioritize goals when working with mentees. Given their relationship with later thriving, the Six Cs of Positive Youth Development (i.e., competence, confidence, connection, character, caring/compassion, and contribution) offer a promising framework that can help mentors as they work with mentees and other key adults (e.g., caregivers) to establish goals for how the mentoring relationship can foster the mentee’s development. Following a discussion of the overall impact of mentoring in the literature, this chapter summarizes evidence on the role mentoring can play in developing the Six Cs. After sharing evidence linking mentoring with the development of all Six Cs, we provide illustrations of how awareness of this framework may benefit mentors generally and, more specifically, be helpful to professional mentors.