This chapter presents evidence-informed theory and research from the international community relevant to professional mentoring in Ghana. Historically, mentoring can be traced as informally practiced since the foundation of the Gold Coast (currently Ghana) in 1821. Primarily, it was observed in the extended family system where grandparents, uncles, and aunties serve as role models for children to live up to culturally approved values, a method known as kinship care. Emerging studies, however, suggest the need for more formalized mentoring in Ghana. However, formal, including professional, youth mentoring is fairly new and underdeveloped. Using Arksey and O'Malley's (2005) scoping studies approach, 2 studies out of 430 screened articles suggest that professional mentoring has a promising impact on child labor trafficking prevention and agricultural and educational advancement in Ghana. The results, limitations, and recommendations for future directions are discussed.