This chapter explores the role of science and technology parks as platforms for institutional bridging mechanisms within innovation systems. Drawing on comparative case studies of BH-Tec in Brazil and PIIT in Mexico, it examines how these parks contribute to regional innovation by facilitating knowledge exchange, capability-building, and inter-organisational collaboration. While BH-Tec reflects a network learning trajectory centred on selective external engagement and entrepreneurial support, PIIT embodies a more orchestrated form of institutional integration through state-led planning and public research infrastructure. The chapter assesses each park’s functions, supporting elements, and knowledge channels. Findings highlight that while both parks enable critical innovation functions, their impact depends on relational infrastructure, incentive alignment, and long-term policy continuity. The analysis underlines the importance of non-firm actors and intermediary institutions in shaping the conditions under which innovation emerges in peripheral and middle-income regions.