Artificial Intelligence (AI) has revolutionized the healthcare sector by enhancing diagnostics, personalized treatment, medical imaging, and patient care. This review discusses the various application areas of AI in various fields like pathology, transplant medicine, epidemiology, integrative medicine, and metrology for AI validation. The current chapter discusses on how AI and human intelligence are moulding the modern society while collaborating the challenges and ethical considerations in detailed manner. Further, the concepts of bias, security privacy are discussed. Subsequently, the chapter throws light on the AI and human intelligence and its future and their distinctions followed by discussing the healthcare professional perspectives while conjointly entailing the strategies for enriching perspectives towards AI. Afterwards, we have discussed about the applications of AI in medicine. Finally, the paper is concluded with further future direction. In toto, the review briefly explains the need for a combined AI-human work where the computational capability of AI is harnessed to the fullest without losing the human essence of medicine.