The chapter argues that effective lessons can be drawn from precolonial Africa’s approaches to how practitioners in African Indigenous Religion handled and managed matters of health, such as how to manage the pervasiveness of epidemics, sustenance of food cultures from identification, preparation and food preservation, as well as how to resolve disputes in the community in order to ensure people’s healthy social relationships. The chapter maintains that traditional institutions that offered broad knowledge pertaining to matters of health, for example, preventive measures and remedies against epidemics, were enervated during the era of Africa’s colonization. It further argues that despite having gone through such disheartening experiences in the recent past, Africa can still make use of the past in order to curb the effects of pandemics. As a necessary strategy, the chapter suggests that there is a need to re-engage integral traditional mechanisms, such as sacred institutions and practitioners, to fully execute their advisory and coordination obligations. The chapter questions the disinclined attitudes against the use of traditional medicine and food in people’s daily lives, but resorting to them as a desperate gesture during moments of crisis. Emphasis is made that Africa has to rethink and embrace indigenous knowledge systems. By doing this, lessons can be drawn from past experiences where indigenous knowledge has been found useful. This enables the proper management of future health crises in Southern Africa.