In this chapter we delve into discussing the intricate interplay of sacred and ethical dimensions in navigating the realms of religion, health, and Sustainable Development Goals (SDGs) within the exclusive and complex context of Africa. Aware of the profound influence of religious beliefs on individual and communal well-being, we examine ethical considerations inherent in health initiatives that seek to align with SDG goals, especially goal 3 on good health and wellbeing. Using a non-empirical desk research approach, we address the diverse religious landscapes across the African continent, exploring how faith traditions shape perceptions of health, community, and achievement of SDGs. By emphasizing the importance of culturally sensitive and ethically grounded approaches, we also examine the potential synergy between religious values and the pursuit of health-related SDGs. Although challenges such as religious diversity, historical contexts, and socio-economic factors stand as impediments to the intercourse among religion, health, and achieving SDGs in Africa, we seek to propose a nuanced understanding that fosters holistic well-being while respecting individual and collective ethical frameworks. By navigating the delicate balance between the sacred and the ethical, we contribute to a comprehensive discourse on fostering sustainable development through the integration of religious values into health institutions and systems in the African context.